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The investigator was blinded to the group allocation during the experiment

(2007) Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane

Patients with inflammatory bowel disease, diverticular disease, haemorrhoids, recent colorectal surgery, cardiovascular conditions, pregnancy, severe renal or cardiac impairment, coagulopathy, or recent pelvic radiotherapy face heightened risks

Besides, different clinical studies suggest that mTOR pathway inhibitor rapamycin can attenuate and prevent epileptogenesis, and could be effective in treating intractable epilepsy (Ostendorf and Wong 2015)